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Related Experiment Video

Updated: Oct 9, 2025

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Optimal Breast Density Characterization Using a Three-Dimensional Automated Breast Densitometry System.

Reika Yoshida1,2, Takenori Yamauchi2, Sadako Akashi-Tanaka1

  • 1Department of Breast Surgical Oncology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.

Current Oncology (Toronto, Ont.)
|December 23, 2021
PubMed
Summary

Dense breasts increase breast cancer risk. Combining mammography (MMG) with ultrasonography (US) improves detection, especially for high-density breasts lacking suspicious calcifications.

Keywords:
Volparabreast densitybreast neoplasmsmammographyultrasonography

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Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging

Background:

  • Dense breasts are a significant risk factor for breast cancer.
  • Mammographic density assessment is crucial but often subjective.
  • Objective measurement tools are needed for accurate breast density evaluation.

Purpose of the Study:

  • To objectively measure mammographic density using Volpara™.
  • To evaluate the combined use of mammography (MMG) and ultrasonography (US) for breast cancer detection.
  • To identify criteria for optimizing supplementary US use in dense breasts.

Main Methods:

  • A case series of 441 patients undergoing primary breast cancer surgery.
  • Objective mammographic density measurement using Volpara™ (Volpara Density Grade - VDG).
  • Analysis of diagnostic accuracy, US detection rates, and calcification status in relation to breast density.

Main Results:

  • Breast density, measured by VDG, was higher in younger patients.
  • Mammographic (MMG) diagnostic accuracy decreased with increasing breast density.
  • Ultrasonography (US) detection rates were independent of VDG and effective across all densities.
  • High risk of missed cancers in patients without suspicious calcifications.

Conclusions:

  • Supplementary US improves breast cancer detection in patients with high breast density (≥25.5%) and no suspicious MMG calcifications.
  • Objective density measurement aids in tailoring screening strategies.
  • Combined MMG and US offer improved diagnostic performance for dense breasts.