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RFID-Based Microwave Biosensor for Non-Contact Detection of Glucose Solution.

Minjia Gao1, Tian Qiang1, Yangchuan Ma1

  • 1Department of Electronic Engineering, School of Internet of Things Engineering, Jiangnan University, Wuxi 214122, China.

Biosensors
|December 23, 2021
PubMed
Summary

This study introduces a novel radio-frequency identification (RFID) glucose biosensor for non-contact glucose monitoring. The developed sensor demonstrates high sensitivity and rapid response, offering a feasible solution for diabetes management.

Keywords:
RFIDcomplementary split-ring resonatorglucose concentrationmicrowave biosensornon-contact measurement

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Area of Science:

  • Biomedical Engineering
  • Microwave Engineering
  • Sensor Technology

Background:

  • Rising prevalence of diabetes necessitates accurate and accessible glucose monitoring.
  • Current glucose monitoring methods present limitations in terms of invasiveness and response time.
  • Microwave biosensors offer potential for non-contact and rapid detection.

Purpose of the Study:

  • To develop and evaluate a novel radio-frequency identification (RFID) based microwave biosensor for non-contact glucose concentration measurement.
  • To assess the sensitivity, detection limit, and response time of the proposed biosensor.
  • To provide a feasible technological solution for improved diabetes monitoring.

Main Methods:

  • Design of a RFID reader using a complementary split-ring resonator (CSRR).
  • Integration of a squared spiral capacitor (SSC) Tag with a microfluidic cavity for glucose solution handling.
  • Characterization of biosensing response by analyzing changes in resonant frequency due to varying glucose concentrations.
  • Performance evaluation including sensitivity, detection limit, and response time.

Main Results:

  • The RFID-based biosensor achieved a sensitivity of 10.27 kHz/mg·dL⁻¹ and a detection limit of 1.19 mg/dL.
  • A rapid response time of less than 1 second was observed.
  • Excellent linear relationship was confirmed through regression analysis, validating the sensor's performance.
  • Comparison with a bare CSRR sensor showed significant improvements in detection limit and sensitivity.

Conclusions:

  • The proposed RFID microwave biosensor enables accurate, non-contact glucose concentration measurement.
  • The sensor design offers high sensitivity and a fast response time, crucial for effective diabetes management.
  • This technology presents a promising advancement in the field of glucose biosensing.