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Stenosis of the Inferior Vena Cava: A Murine Model of Deep Vein Thrombosis
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Mortality of Patients Infected by COVID-19 with and without Deep-Vein Thrombosis

Jose Maria Pereira de Godoy1, Gleison Juliano da Silva Russeff2, Carolina Hungaro Costa2

  • 1Cardiovascular Surgery Department, Sao Jose do Rio Preto School of Medicine (FAMERP), Undergraduate Medicine Course and Stricto Sensu Postgraduate Course (FAMERP) and CNPq (National Council for Research and Development), São Jose do Rio Preto 15025120, Brazil.

Medicines (Basel, Switzerland)
|December 23, 2021
PubMed

Insights

Deep-vein thrombosis (DVT) significantly increases mortality in COVID-19 patients. Conventional prophylaxis may fail, highlighting the need for improved DVT management strategies in SARS-CoV-2 infections.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Cardiology

Background:

  • COVID-19 is associated with hyperinflammation, leading to hypercoagulability.
  • Hypercoagulability is a key pathogenic mechanism contributing to increased COVID-19 mortality.
  • The role of deep-vein thrombosis (DVT) in SARS-CoV-2 mortality requires further investigation.

Purpose of the Study:

  • To investigate the influence of deep-vein thrombosis (DVT) on mortality in patients infected with SARS-CoV-2.
  • To assess the association between DVT and mortality outcomes in COVID-19 patients.

Main Methods:

  • A clinical trial was conducted involving 200 consecutive COVID-19 patients.
  • Patients were divided into two groups: 100 positive for DVT (diagnosed via venous Doppler ultrasound) and 100 negative for DVT.
  • Mortality rates were compared between the DVT-positive and DVT-negative groups.

Main Results:

  • The mortality rate in the DVT-positive group was 67%.
  • The mortality rate in the DVT-negative group was 31%.
  • A significant difference in mortality was observed between the two groups.

Conclusions:

  • Deep-vein thrombosis is strongly associated with increased mortality in COVID-19 patients.
  • Conventional prophylaxis for DVT may be insufficient in managing SARS-CoV-2 infected patients.
  • Further research into advanced DVT prevention and treatment strategies for COVID-19 is warranted.
Abstract

Keywords:
COVID-19Dopplerdeep-vein thrombosismortalityultrasound

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