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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

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Marine Terpenic Endoperoxides.

Irene Torres-García¹, Josefa L López-Martínez¹, Manuel Muñoz-Dorado¹

¹Organic Chemistry, University of Almería, ceiA3, E04120 Almería, Spain.

|December 23, 2021

Summary

This summary is machine-generated.

Marine sponges yield compounds with anticancer and antibiotic properties, often featuring a 1,2-dioxane ring. This review focuses on terpene-derived natural products with this endoperoxide function and their biological activities.

Keywords:

endoperoxide marine terpenoid norditerpene norseterterpene sponge

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Area of Science:

Marine Natural Products Chemistry
Medicinal Chemistry
Organic Chemistry

Background:

Marine invertebrates, particularly sponges, are rich sources of bioactive compounds.
Many discovered compounds possess anticancer and antibiotic activities, indicating pharmaceutical potential.
A common structural motif is the 1,2-dioxane ring, an endoperoxide function.

Purpose of the Study:

To provide a comprehensive review of terpene-derived natural products containing the endoperoxide function.
To focus on the structural features and biological activities of these specific marine compounds.
To address a gap in existing reviews by concentrating on terpene endoperoxides from marine sources.

Main Methods:

Literature review of scientific publications from the 1970s to the present.
Analysis of structural elucidation and total synthesis studies.
Compilation of data on biological activities, including anticancer and antibiotic properties.

Main Results:

Terpene-based compounds, primarily diterpenes and sesterterpenes, frequently exhibit the 1,2-dioxane endoperoxide moiety.
These compounds often display unique structural characteristics, such as variations in carbon count.
The endoperoxide function is strongly correlated with observed biological activities.

Conclusions:

Terpene endoperoxides from marine invertebrates represent a significant class of bioactive natural products.
Their unique structures and potent activities make them valuable leads for pharmaceutical development.
Further research into these compounds could unlock novel therapeutic agents.