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Correction: Assalve et al. Marine Algal Metabolites as Cellular Antioxidants: A Study of Caulerpin and Caulerpinic Acid in <i>Saccharomyces cerevisiae</i>. <i>Mar. Drugs</i> 2025, <i>23</i>, 338.

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Anti-Inflammatory Activity of Fucoidan Extracts In Vitro.

Tauseef Ahmad1, Mathew Suji Eapen2, Muhammad Ishaq3

  • 1School of Health Sciences, University of Tasmania, Launceston, TAS 7248, Australia.

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|December 23, 2021
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Summary
This summary is machine-generated.

Fucoidan extracts from brown seaweeds show significant anti-inflammatory effects by reducing pro-inflammatory cytokines. Lower molecular weight fucoidans, particularly from Macrocystis pyrifera, are most effective at lower concentrations.

Keywords:
Ascophyllum nodosumFucus vesiculosusLaminaria japonicaMacrocystis pyriferaPBMCsTHP-1TNF-α, IL-1β, and IL-6Undaria pinnatifidafucoidan

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Area of Science:

  • Marine natural products
  • Immunology
  • Pharmacology

Background:

  • Fucoidans are complex polysaccharides derived from brown seaweeds.
  • They possess diverse bioactivities, including potent anti-inflammatory properties.
  • Fucoidans modulate inflammation through mechanisms like selectin blockade and enzyme inhibition.

Purpose of the Study:

  • To evaluate the anti-inflammatory potential of fucoidan extracts from five different brown seaweed species.
  • To assess the impact of fucoidans on pro-inflammatory cytokine production in human immune cells.
  • To investigate the role of molecular weight in fucoidan efficacy.

Main Methods:

  • Fucoidan extracts were prepared from Undaria pinnatifida, Fucus vesiculosus, Macrocystis pyrifera, Ascophyllum nodosum, and Laminaria japonica.
  • Cytotoxicity of fucoidan extracts was assessed in THP-1 cells.
  • Pro-inflammatory cytokine production (TNF-α, IL-1β, IL-6) was measured in lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells (PBMCs) and THP-1 cells.

Main Results:

  • Fucoidan extracts showed no cytotoxicity in THP-1 cells after 48h incubation.
  • All tested fucoidan extracts dose-dependently reduced pro-inflammatory cytokine production in LPS-stimulated PBMCs and THP-1 cells.
  • A 5-30 kDa subfraction from Macrocystis pyrifera demonstrated particularly high inhibitory activity at low concentrations.

Conclusions:

  • Fucoidan extracts from various seaweed species exhibit significant anti-inflammatory effects.
  • Lower molecular weight fucoidan subfractions demonstrate enhanced efficacy at reduced concentrations.
  • These findings provide insights for optimizing fucoidan-based strategies against inflammation-related diseases.