Research advances on surface plasmon resonance biosensors

Area of Science:

• Biomedical Engineering
• Analytical Chemistry
• Biosensing Technology

Background:

• Surface plasmon resonance (SPR) is a highly sensitive optical phenomenon used for label-free detection.
• SPR biosensors are crucial for rapid and sensitive biomarker identification.
• Advances in SPR technology are vital for modern bio-detection.

Purpose of the Study:

• To review the latest research on SPR biosensors for bio-detection.
• To analyze different substrate structures and surface materials for SPR sensors.
• To explore surface plasmon resonance imaging (SPRI) and SPR-enhanced electrochemiluminescent (ECL) biosensors.

Main Methods:

• Review of recent literature on SPR, SPRI, and SPR-ECL biosensors.
• Analysis of SPR biosensor characteristics based on substrate (prisms, gratings, optical fibers).
• Evaluation of surface modification materials (dielectric films, nanostructures, antifouling layers).

Main Results:

• SPR biosensors show high sensitivity and interference resistance with optimized structures and materials.
• SPRI technology is advancing for biomedical detection applications.
• SPR-enhanced ECL biosensors demonstrate significant progress in biosensing.

Conclusions:

• SPR biosensors are versatile tools for sensitive bio-detection.
• Future trends include portable SPR sensors and improved ECL sensor designs.
• Continued development in SPR and related technologies will enhance diagnostic capabilities.