Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

908
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
908
Antigen Processing Pathways01:31

Antigen Processing Pathways

1.4K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
1.4K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

771
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
771
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

8.1K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
8.1K
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

2.6K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.6K
Cross-reactivity00:42

Cross-reactivity

31.7K
Overview
31.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of cross-stage, cross-species malaria CD8<sup>+</sup> T cell antigens.

Nature·2026
Same author

Stable β2-Microglobulin-HLA Class I Association Reshapes the Antigenic Landscape and TCR Recognition of Cancer-Associated Epitopes.

European journal of immunology·2026
Same author

Machine learning in AIRR diagnostics: Advances and applications.

Immunoinformatics (Amsterdam, Netherlands)·2026
Same author

OPN-Derived Peptides Generated by Proteasomes Can Promote Cell Migration via CD44 Activation.

Journal of immunology research·2026
Same author

nuTCRacker: Predicting the Recognition of HLA-I-Peptide Complexes by αβTCRs for Unseen Peptides.

European journal of immunology·2025
Same author

Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing.

Nature communications·2024

Related Experiment Video

Updated: Oct 9, 2025

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

9.9K

Mechanistic diversity in MHC class I antigen recognition.

Camila R R Barbosa1,2, Justin Barton3, Adrian J Shepherd3

  • 1Centre for Inflammation Biology and Cancer Immunology (CIBCI) & Peter Gorer Department of Immunobiology, King's College London, SE1 1UL London, U.K.

The Biochemical Journal
|December 23, 2021
PubMed
Summary

The human immune system diversifies CD8+ T cell targets through various mechanisms. This review examines antigen presentation diversity and T cell receptor cross-recognition, focusing on controversial unconventional peptides.

Keywords:
MHC class IT cellsTCRantigensspliced peptides

More Related Videos

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
09:53

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Published on: February 6, 2017

11.6K
Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous &#946;2-Microglobulin
11:17

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

Published on: March 10, 2021

6.5K

Related Experiment Videos

Last Updated: Oct 9, 2025

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

9.9K
Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
09:53

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Published on: February 6, 2017

11.6K
Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous &#946;2-Microglobulin
11:17

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

Published on: March 10, 2021

6.5K

Area of Science:

  • Immunology
  • Molecular Biology
  • T cell biology

Background:

  • The human immune system employs sophisticated strategies to generate diverse antigenic peptide targets for CD8+ T cells.
  • Understanding antigen presentation by MHC class I molecules is crucial for adaptive immunity against pathogens and self-aberrations.

Purpose of the Study:

  • To provide a comprehensive overview of mechanisms generating antigen diversity presented by MHC class I.
  • To analyze recent advancements in two controversial areas: unconventional antigen peptides and CD8+ T cell receptor cross-recognition.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of recent findings on MHC class I antigen processing and presentation.
  • Detailed examination of studies investigating unconventional peptides and T cell receptor cross-reactivity.

Main Results:

  • Multiple mechanisms contribute to the diversity of peptides presented by MHC class I molecules.
  • Significant debate exists regarding the prevalence and immunological significance of unconventional antigen peptides.
  • T cell receptor cross-recognition of structurally similar peptides is a notable feature of CD8+ T cell responses.

Conclusions:

  • The diversity of presented antigens is essential for effective immune surveillance.
  • Further research is needed to clarify the role of unconventional peptides in immunity and disease.
  • Understanding T cell receptor cross-recognition is key to predicting and manipulating T cell responses.