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Updated: Oct 9, 2025

A Real-World High-Intensity Interval Training Protocol for Cardiorespiratory Fitness Improvement
Published on: February 22, 2022
Physiological Responses to Low-Volume Interval Training in Women.
Lauren E Skelly1, Celine Bailleul2, Jenna B Gillen3
1School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, ON, Canada.
Low-volume interval training, including high-intensity interval training (HIIT) and sprint interval training (SIT), effectively improves cardiorespiratory fitness in women. However, responses in insulin sensitivity and muscle mitochondria require further investigation, particularly comparing women and men.
Area of Science:
- Exercise Physiology
- Sports Science
- Metabolic Health
Background:
- Low-volume interval training (high-intensity interval training [HIIT] and sprint interval training [SIT]) offers time-efficient exercise benefits.
- Most research has focused on men, leaving a gap in understanding women's physiological responses across the lifespan.
- Existing studies often lack direct sex comparisons, limiting insights into adaptive differences.
Purpose of the Study:
- To review physiological responses to low-volume interval training in women, including those with overweight/obesity or type 2 diabetes.
- To focus on cardiorespiratory fitness, glycemic control, and skeletal muscle mitochondrial adaptations.
- To compare the adaptive responses between women and men.
Main Methods:
- Systematic review of existing literature on interval training in women.
- Analysis of studies focusing on cardiorespiratory fitness, glycemic control, and muscle mitochondrial content.
- Inclusion of research comparing male and female responses to HIIT and SIT.
Main Results:
- HIIT and SIT consistently improve cardiorespiratory fitness in women, with similar gains observed compared to men.
- Evidence regarding insulin sensitivity and skeletal muscle mitochondrial responses in women is limited and conflicting.
- Some studies suggest potentially blunted improvements in insulin sensitivity in women relative to men.
Conclusions:
- Low-volume interval training is effective for improving cardiorespiratory fitness in women.
- Further research is needed to clarify sex-specific differences in metabolic and mitochondrial adaptations to interval training.
- More studies are required to inform evidence-based physical activity recommendations for women.
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