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Updated: Oct 9, 2025
Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
Published on: July 21, 2013
Cerebral large artery occlusion in chronic graft-versus-host disease: A case report
1Department of Neurology, Peking University First Hospital, Beijing, China.
Rationale:
Cerebral large artery occlusion in chronic central nervous system graft-versus-host disease after allogeneic hematopoietic stem cell transplantation (allo-HSCT) was very scarce. We described a young patient with bilateral white matter lesions and symptomatic internal carotid artery occlusion after allo-HSCT with the history of aplastic anemia.
Patient Concerns:
A 17-year-old girl with the history of aplastic anemia developed recurrent headache and sudden hemiplegia of right limbs 2 years after allo-HSCT.
Diagnoses:
She was diagnosed with skin chronic graft-versus-host disease 19 months after allo-HSCT. Brain magnetic resonance imaging showed bilateral subcortical white matter abnormal signals and hyperintensity of left fronto-parietal lobe on diffusion weighted imaging and corresponding hypointense apparent diffusion coefficients indicating acute infarction. CT angiography revealed thrombosis in left internal carotid artery. Carotid plaque high-resolution magnetic resonance imaging showed annular enhancement of vascular wall revealing signs of vasculitis.
Interventions:
Intravenous immunoglobulin, methylprednisolone, and anticoagulant therapy were used to treat the patient.
Outcomes:
The patient's symptoms gradually resolved and she could walk with assistance after 3 weeks before returned home.
Lessons:
Chronic graft-versus-host disease-associated vasculitis could involve cerebral large vessels which warrants further study.
