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Updated: Jul 25, 2026

Murine Heterotopic Heart Transplant Technique
Published on: July 8, 2014
Parvovirus B19-induced severe anemia in heart transplant recipient: A case report
Bijun Xu1, Weimin Zhang, Ximing Qian
1Department of Cardiovascular Surgery, Sir Run Run Shaw Hospital, Zhejiang University, China.
Rationale:
Human parvovirus B19 (B19V) is a non-enveloped single-stranded DNA virus associated with a variety of human diseases. Reports of B19V infection after cardiac transplantation are relatively rare.
Patient Concerns:
We report a case of a 48-year-old women who underwent orthotopic heart transplant for dilated cardiomyopathy. She developed an anemia after cardiac transplantation. Anemia was most severe 2 months after surgery, with a decrease in reticulocyte count. Serological DNA test for parvovirus B19V was performed and the result was positive.
Diagnoses:
B19V infection.
Interventions And Outcomes:
Intravenous immunoglobulin administration resulted in a resolution of the anemia. The patient's blood test results showed a normal hemoglobin and reticulocyte count 1 year after surgery.
Lessons:
Patients with parvovirus B19V infection may develop severe anemia after heart transplantation. The diagnosis mainly relies on viral DNA detection. Intravenous immunoglobulin is an effective treatment for viral infection.
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