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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...

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Updated: May 6, 2026

Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling

Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling

Published on: June 23, 2022

A new tool to probe SARS-CoV-2 variants.

Bryan A Johnson¹, Vineet D Menachery^1,2,3,4

¹Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.

Science (New York, N.Y.)

|December 23, 2021

Summary

Virus-like particles provide a novel method for studying genetic changes in SARS-CoV-2. This approach enhances our understanding of viral evolution and the spread of the severe acute respiratory syndrome coronavirus 2.

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Area of Science:

Virology
Genetics
Molecular Biology

Background:

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits significant genetic variation.
Understanding SARS-CoV-2 genetic diversity is crucial for tracking its evolution and spread.
Existing methods for analyzing viral genetic variation have limitations.

Purpose of the Study:

To introduce and evaluate virus-like particles (VLPs) as a novel tool for investigating SARS-CoV-2 genetic variation.
To demonstrate the utility of VLPs in capturing and analyzing genetic diversity within SARS-CoV-2 populations.

Main Methods:

Development and characterization of SARS-CoV-2 virus-like particles.
Application of VLPs to sample and detect genetic variations in SARS-CoV-2.
Comparative analysis of VLP-based methods with conventional sequencing techniques.

Main Results:

Virus-like particles successfully recapitulated key features of SARS-CoV-2.
VLP-based approach demonstrated sensitivity in identifying known and novel SARS-CoV-2 genetic variants.
The method proved efficient for high-throughput genetic variation analysis.

Conclusions:

Virus-like particles represent a promising and innovative platform for the comprehensive investigation of SARS-CoV-2 genetic variation.
This VLP-based strategy offers advantages for real-time monitoring of viral evolution and the emergence of new strains.