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Clonal Wars: Monoclonal Antibodies Against Infectious Pathogens
1Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.
DNA and Cell Biology
|December 23, 2021
Summary
Monoclonal antibodies are effective tools against infectious diseases like COVID-19. Our research focuses on developing bispecific antibodies to neutralize SARS-CoV-2 variants, even with vaccines available.
Area of Science:
- Immunology
- Virology
- Infectious Disease Research
Background:
- Monoclonal antibodies (mAbs) are increasingly vital for preventing infectious diseases.
- The COVID-19 pandemic highlighted the significance of mAbs in pathogen control.
- The efficacy of mAbs is debated, particularly when vaccines are also available.
Purpose of the Study:
- To discuss the role of monoclonal antibodies in infectious disease prevention.
- To describe the identification of human monoclonal antibodies against SARS-CoV-2.
- To present findings on bispecific antibodies neutralizing SARS-CoV-2 variants of concern.
Main Methods:
- Review of monoclonal antibody applications in infectious disease.
- Description of efforts to discover human monoclonal antibodies against SARS-CoV-2.
- Characterization of novel bispecific antibodies for SARS-CoV-2 neutralization.
Main Results:
- Monoclonal antibodies show promise for infectious disease prevention.
- Potent human monoclonal antibodies against SARS-CoV-2 have been identified.
- Bispecific antibodies demonstrate neutralization of SARS-CoV-2 variants.
Conclusions:
- Monoclonal antibodies are valuable tools, complementing vaccines.
- Targeted antibody therapies are crucial for combating evolving viral threats.
- Bispecific antibody strategies offer potential for broad-spectrum neutralization.
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