New Indication for Cabozantinib.
1Diane S. Aschenbrenner is a former member of the faculty at Notre Dame of Maryland University and the Johns Hopkins University School of Nursing. She coordinates Drug Watch : diane.aschenbrenner@gmail.com .
The American Journal of Nursing
|December 23, 2021
Summary
Cabozantinib (Cabometyx) is approved for advanced differentiated thyroid cancer. It treats patients whose disease progressed after prior targeted therapies.
Area of Science:
- Oncology
- Pharmacology
Background:
- Differentiated thyroid cancer (DTC) can become locally advanced or metastatic.
- Progression after vascular endothelial growth factor receptor (VEGFR)-targeted therapy presents a treatment challenge.
Purpose of the Study:
- To summarize the approval of Cabozantinib (Cabometyx) for specific DTC patient populations.
Main Methods:
- Review of clinical trial data and regulatory submissions.
- Assessment of efficacy and safety in patients with progressive DTC.
Main Results:
- Cabozantinib demonstrated efficacy in patients with differentiated thyroid cancer.
- The drug is indicated for those with locally advanced or metastatic disease.
Conclusions:
- Cabozantinib provides a new therapeutic option for advanced DTC.
- This approval addresses an unmet need for patients progressing on prior VEGFR-targeted treatments.
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