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Updated: Oct 9, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.4K

Circular RNAs in renal cell carcinoma: Functions in tumorigenesis and diagnostic and prognostic potentials

Arezou Sayad1, Sajad Najafi2, Amir Hossein Kashi3

  • 1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pathology, Research and Practice
|December 23, 2021
PubMed

Insights

Circular RNAs (circRNAs) are key regulators in cell processes. This review explores their roles in renal cell carcinoma (RCC), highlighting their potential as diagnostic and prognostic biomarkers for cancer.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are covalently closed non-coding RNA molecules resistant to exonucleases.
  • They exhibit cell- and tissue-specific expression patterns.
  • circRNAs play crucial roles in regulating gene expression and cellular functions, including cell cycle and proliferation.

Purpose of the Study:

  • To review the tumorigenic and tumor-suppressing roles of circRNAs in renal cell carcinoma (RCC).
  • To assess the diagnostic and prognostic potential of circRNAs in RCC.
  • To explore circRNAs as potential biomarkers for RCC diagnosis and prognosis.

Main Methods:

  • Literature review of studies investigating circRNAs in RCC.
  • Analysis of high-throughput data identifying differentially expressed circRNAs in RCC.
  • Evaluation of the correlation between circRNA expression and clinicopathological features, prognosis, and survival in RCC patients.

Main Results:

  • Dysregulated circRNAs are implicated in RCC carcinogenesis.
  • Overexpressed circRNAs can promote tumorigenic functions, while down-regulated circRNAs may repress them.
  • Aberrant circRNA expression correlates with clinicopathological features, prognosis, and survival in RCC patients, indicating diagnostic and prognostic value.

Conclusions:

  • circRNAs possess significant tumorigenic or tumor-suppressing effects in RCC.
  • circRNAs demonstrate potential as valuable biomarkers for RCC diagnosis and prognosis.
  • Further research into circRNAs could lead to novel therapeutic strategies for RCC.
Keywords:
BiomarkerCircular RNAMiRNARCCRenal cell carcinomaTumorigenesis

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