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Updated: Oct 9, 2025

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Radioresistance in Prostate Cancer: Focus on the Interplay between NF-κB and SOD

Sameera Kumar1, Daret St Clair2

  • 1Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

Antioxidants (Basel, Switzerland)
|December 24, 2021
PubMed

Insights

Superoxide dismutase enzymes protect against prostate cancer by neutralizing harmful reactive oxygen species. Targeting the NF-κB pathway can overcome radioresistance in aggressive prostate cancer.

Area of Science:

  • Oncology
  • Biochemistry
  • Molecular Biology

Background:

  • Prostate cancer is a frequent and potentially lethal malignancy in men.
  • Oxidative stress from free radicals and reactive oxygen species contributes to cancer initiation.
  • Superoxide dismutase (SOD) enzymes detoxify reactive oxygen species, offering protection against prostate cancer.

Purpose of the Study:

  • To explore the role of superoxide dismutase in prostate cancer progression and radioresistance.
  • To investigate the link between superoxide dismutase 2, NF-κB signaling, and treatment resistance.
  • To identify potential therapeutic targets for overcoming radioresistance in aggressive prostate cancer.

Main Methods:

  • Review of existing literature on oxidative stress, SOD enzymes, and prostate cancer.
  • Analysis of molecular pathways involved in cancer radioresistance, including NF-κB.
  • Examination of the relationship between SOD activity and tumor aggressiveness.

Main Results:

  • Increased superoxide dismutase activity is generally protective against prostate cancer.
  • Aggressive prostate tumors often exhibit radioresistance.
  • Superoxide dismutase 2, induced by NF-κB, is a key factor in prostate cancer radioresistance.

Conclusions:

  • Superoxide dismutase plays a dual role in prostate cancer, offering protection but also contributing to radioresistance via NF-κB.
  • Targeting the NF-κB pathway presents a promising strategy for enhancing the efficacy of radiation therapy in prostate cancer.
  • Understanding these mechanisms can lead to novel therapeutic interventions for advanced prostate cancer.
Keywords:
NF-κBprostate cancerradiationsuperoxide dismutase

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