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The KEAP1-NRF2 System in Healthy Aging and Longevity.
Daisuke Matsumaru1, Hozumi Motohashi2
1Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-Nishi, Gifu 501-1196, Japan.
Antioxidants (Basel, Switzerland)
|December 24, 2021
Summary
Environmental factors like oxidative stress significantly impact aging. The Kelch-like ECH-associated protein 1-NFE2-related factor 2 (KEAP1-NRF2) system defends against this stress, offering insights into extending healthspan and treating age-related diseases.
Area of Science:
- Cellular and Molecular Biology
- Gerontology
- Environmental Health
Background:
- Aging is influenced by environmental factors, with oxidative stress from reactive oxygen species being a major contributor.
- The Kelch-like ECH-associated protein 1-NFE2-related factor 2 (KEAP1-NRF2) system is a key cellular defense against oxidative and electrophilic insults.
- Dysregulation of the KEAP1-NRF2 pathway is implicated in aging and age-related diseases.
Purpose of the Study:
- To review the relationship between oxidative stress and aging across various systems (sensory, glandular, muscular, central nervous).
- To elucidate the role of the KEAP1-NRF2 system in mitigating aging processes and age-related damage.
- To explore how understanding stress responses can inform strategies for healthspan extension.
Main Methods:
- Literature review of studies on oxidative stress, aging, and the KEAP1-NRF2 pathway.
- Analysis of research linking environmental factors to organismal aging.
- Synthesis of findings on KEAP1-NRF2 system's role in cytoprotection and detoxification.
Main Results:
- Oxidative stress significantly contributes to aging-related alterations in multiple organ systems.
- The KEAP1-NRF2 pathway plays a crucial role in cellular defense against oxidative damage, impacting aging.
- Studies demonstrate the KEAP1-NRF2 system's involvement in preventing and attenuating physiological aging.
Conclusions:
- Targeting the KEAP1-NRF2 system offers potential therapeutic strategies for age-related diseases.
- Controlling stress-induced damage through pathways like KEAP1-NRF2 may extend healthspan.
- Further research into oxidative stress and KEAP1-NRF2 interactions is vital for aging interventions.
Keywords:
Alzheimer’s diseaseKEAP1-NRF2 systemage-related hearing lossagingcell senescencelongevityoxidative stresssarcopeniatissue agingMore Related Videos
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