Related Experiment Video

Updated: Oct 9, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

9.0K

An Insight into GPCR and G-Proteins as Cancer Drivers

Preeti Kumari Chaudhary1, Soochong Kim1

  • 1Laboratory of Veterinary Pathology and Platelet Signaling, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea.

Cells
|December 24, 2021
PubMed

Insights

G-protein-coupled receptors (GPCRs) are crucial in cancer progression. This review explores GPCRs

Area of Science:

  • Oncology and Molecular Biology: Focuses on cell surface receptors and their role in cancer.

Background:

  • G-protein-coupled receptors (GPCRs) are key cell surface signaling receptors involved in numerous physiological functions.
  • GPCRs mediate cellular responses to various external molecules like hormones and neurotransmitters.
  • Aberrant GPCR activity is implicated in cancer development, affecting tumor growth, metastasis, and survival.

Purpose of the Study:

  • To provide insights into the diverse responses mediated by GPCRs in cancer development.
  • To elucidate the molecular mechanisms underlying GPCR involvement in cancer progression.
  • To review novel pharmacological approaches for targeting GPCRs in cancer therapy.

Main Methods:

  • This study is a review of existing literature on GPCRs in cancer.
  • It synthesizes information on GPCR signaling pathways and their connection to cancer.
  • The review also covers current and emerging therapeutic strategies targeting GPCRs.

Main Results:

  • GPCRs play a significant role in various stages of cancer, including tumor growth, invasion, migration, survival, and metastasis.
  • While GPCRs' involvement in cancer is recognized, the precise molecular mechanisms remain complex and require further investigation.
  • Aberrant GPCR expression, mutations, or agonist release contribute to cancer progression.

Conclusions:

  • Understanding GPCRs' multifaceted roles in cancer is essential for developing effective treatments.
  • This review enhances knowledge of GPCRs in cancer cells, aiding in the identification of potential therapeutic targets.
  • Novel pharmacological strategies targeting GPCRs offer promising avenues for cancer patient treatment.
Keywords:
G-proteinGPCRGPCR signalingcancer

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