Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

5.1K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolving Landscape of Glioblastoma Research: Integrating Therapeutic Advances and Diagnostic Frontiers.

Brain sciences·2026
Same author

Oncogenic effects of ECM remodeling in obesity and breast cancer.

Oncogene·2025
Same author

Photophysical Characterization and In Vitro Evaluation of α-Mangostin-Loaded HDL Mimetic Nano-Complex in LN-229 Glioblastoma Spheroid Model.

International journal of molecular sciences·2024
Same author

Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2.

bioRxiv : the preprint server for biology·2024
Same author

The Expression of Adipogenic Marker Is Significantly Increased in Estrogen-Treated Lipedema Adipocytes Differentiated from Adipose Stem Cells In Vitro.

Biomedicines·2024
Same author

Enhanced Angiogenesis in HUVECs Preconditioned with Media from Adipocytes Differentiated from Lipedema Adipose Stem Cells In Vitro.

International journal of molecular sciences·2023
Same journal

RETRACTED: Bakshi et al. Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-kB/VEGF Pathways. <i>Cells</i> 2022, <i>11</i>, 1502.

Cells·2026
Same journal

Correction: Verde et al. Molecular Mechanisms of Protein Aggregation in ALS-FTD: Focus on TDP-43 and Cellular Protective Responses. <i>Cells</i> 2025, <i>14</i>, 680.

Cells·2026
Same journal

Inflammation in Cardiomyopathies: Cellular Mechanisms Across Cardiac Phenotype.

Cells·2026
Same journal

IL-4/IL-13-Driven Dysregulation of Epidermal Lipid Metabolism in Atopic Dermatitis: An Immunometabolic Link Between Type 2 Inflammation and Barrier Dysfunction.

Cells·2026
Same journal

Activity of DNA- and RNA-Guided Prokaryotic Argonautes in Human Mitochondria.

Cells·2026
Same journal

Placental Pathophysiology in Maternal Psychoactive Substance Use: Biological, Clinical, and Forensic Perspectives.

Cells·2026
See all related articles

Related Experiment Video

Updated: Oct 9, 2025

Author Spotlight: Isolation and Identification of Mesenchymal Stem Cells Derived from Adipose Tissue of Sprague Dawley Rats
10:50

Author Spotlight: Isolation and Identification of Mesenchymal Stem Cells Derived from Adipose Tissue of Sprague Dawley Rats

Published on: April 7, 2023

3.6K

Adipose Tissue-Derived Mesenchymal Stem Cells.

Bruce A Bunnell1

  • 1Department of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

Cells
|December 24, 2021
PubMed
Summary
This summary is machine-generated.

Adipose stem cells (ASCs) are potent regenerative medicine tools, offering advantages over other mesenchymal stem cells (MSCs). Their secretome and differentiation potential highlight their therapeutic promise.

Keywords:
adipose stem cellsbiologyclinical trialsdifferentiationhumansecretome

More Related Videos

Isolation of Rat Adipose Tissue Mesenchymal Stem Cells for Differentiation into Insulin-producing Cells
08:09

Isolation of Rat Adipose Tissue Mesenchymal Stem Cells for Differentiation into Insulin-producing Cells

Published on: August 29, 2022

7.8K
Author Spotlight: Advancing Treatment Approaches with Adipose-Derived Stem Cells
04:53

Author Spotlight: Advancing Treatment Approaches with Adipose-Derived Stem Cells

Published on: January 12, 2024

1.1K

Related Experiment Videos

Last Updated: Oct 9, 2025

Author Spotlight: Isolation and Identification of Mesenchymal Stem Cells Derived from Adipose Tissue of Sprague Dawley Rats
10:50

Author Spotlight: Isolation and Identification of Mesenchymal Stem Cells Derived from Adipose Tissue of Sprague Dawley Rats

Published on: April 7, 2023

3.6K
Isolation of Rat Adipose Tissue Mesenchymal Stem Cells for Differentiation into Insulin-producing Cells
08:09

Isolation of Rat Adipose Tissue Mesenchymal Stem Cells for Differentiation into Insulin-producing Cells

Published on: August 29, 2022

7.8K
Author Spotlight: Advancing Treatment Approaches with Adipose-Derived Stem Cells
04:53

Author Spotlight: Advancing Treatment Approaches with Adipose-Derived Stem Cells

Published on: January 12, 2024

1.1K

Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Adipose Tissue Research

Background:

  • Historically viewed as inert, adipose tissue is now recognized for its rich source of adult stromal/stem cells (ASCs).
  • ASCs are increasingly investigated for cellular therapies due to their abundance and ease of isolation compared to other mesenchymal stem cells (MSCs).

Discussion:

  • ASCs exhibit multipotency, differentiating into various mesodermal cell types.
  • The secretome of ASCs, including cytokines and microRNAs, actively modulates tissue biology and immune responses.
  • Donor variability (age, BMI, health status) influences ASC quality and therapeutic efficacy.

Key Insights:

  • ASCs possess significant therapeutic potential, driven by their differentiation capacity and bioactive secretome.
  • The ease of ASC isolation and abundance makes them a promising source for regenerative applications.
  • Understanding ASC secretome action mechanisms is crucial for optimizing their therapeutic use.

Outlook:

  • Further research into ASC action mechanisms and secretome modulation could enhance their clinical utility.
  • Standardizing ASC isolation and characterization methods will be vital for consistent therapeutic outcomes.
  • Exploring ASC applications in diverse therapeutic areas holds significant promise for future regenerative medicine strategies.