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Related Concept Videos

G Protein-coupled Receptors01:15

G Protein-coupled Receptors

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G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
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Transducer Mechanism: G Protein–Coupled Receptors01:30

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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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Adhesion GPCR GPR56 Expression Profiling in Human Tissues.

Fyn Kaiser1, Markus Morawski2, Knut Krohn3

  • 1Research Laboratories and Clinic of Visceral, Transplantation, Thoracic, and Vascular Surgery, Leipzig University and University Hospital Leipzig, 04103 Leipzig, Germany.

Cells
|December 24, 2021
PubMed
Summary
This summary is machine-generated.

This study maps the human G protein-coupled receptor 56 (GPR56) tissue expression. GPR56 is broadly expressed across various human tissues, including the brain, epithelia, thyroid, kidney, and placenta.

Keywords:
ADGRG1GPR56microgliathyroid

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Area of Science:

  • Molecular Biology
  • Immunology
  • Neuroscience

Background:

  • G protein-coupled receptor 56 (GPR56), encoded by the ADGRG1 gene, plays crucial roles in tumorigenesis, immune regulation, and brain development.
  • Despite its functional importance, the precise tissue distribution of GPR56 in humans remains largely uncharacterized.

Purpose of the Study:

  • To establish a comprehensive human GPR56 tissue expression profile.
  • To validate antibodies for reliable GPR56 detection in various immunotechniques.

Main Methods:

  • Antibody validation using GPR56-tagged and ADGRG1-knockout cells.
  • Determination of GPR56 protein expression across human tissues.
  • Correlation analysis with ADGRG1 RNA-sequencing data.

Main Results:

  • A strong correlation was observed between ADGRG1 mRNA levels and GPR56 protein expression across human tissues.
  • GPR56 is prominently expressed in adult brain microglia.
  • Outside the central nervous system, GPR56 is frequently found in secreting epithelial cells of the thyroid, kidney, and placenta, often associated with secreted proteins.

Conclusions:

  • GPR56 exhibits a broad expression pattern in humans, not restricted to specific cell types.
  • The findings provide a foundational understanding of GPR56 localization, aiding future research into its diverse physiological and pathological roles.