[Effect of anti-inflammatory agents and immunostimulants on delayed hypersensitivity]

Combination of nonnarcotic analgetics (antiphlogistic drugs) such as acetylsalicylic acid, indomethacin, voltaren and naproxen and immunostimulators such as prodigiozan, levamisole and methyluracil were studied with respect to their effect on delayed type hypersensitivity (DTH) to dinitrochlorobenzene (DNCB) in noninbred albino rats of both sexes. The drugs were administered after sensitization. It was shown that prodigiozan did not change DTH to DNCB. Levamisole and methyluracil lowered DTH to DNCB. The effect of levamisole was preserved in the presence of indomethacin and voltaren. Indomethacin and voltaren inhibited DTH. Acetylsalicylic acid and naproxen did not change it. Prodigiozan, methyluracil and levamisole did not change the character of the effect of the above antiphlogistic drugs on DTH.