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Updated: Oct 9, 2025
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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Pustular Psoriasis: From Pathophysiology to Treatment
Giovanni Genovese1,2, Chiara Moltrasio1,3, Nicoletta Cassano4
1Dermatology Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Biomedicines
|December 24, 2021
Summary
Pustular psoriasis (PP) involves sterile pustules and is linked to innate immunity, particularly the IL-36 axis. Advances in genetics and immunology offer new insights into its diagnosis and treatment.
Area of Science:
- Dermatology
- Immunology
- Genetics
Background:
- Pustular psoriasis (PP) is a group of disorders characterized by sterile pustules.
- PP variants include generalized, pregnancy-related, annular, infantile/juvenile, palmoplantar, and acrodermatitis continua of Hallopeau.
- Unlike psoriasis vulgaris, PP involves innate immunity hyperactivation and the IL-36 axis.
Purpose of the Study:
- To review current findings on the pathogenesis, classification, clinical features, and therapeutic management of pustular psoriasis.
- To highlight recent advances in understanding PP genetics and immunology.
- To discuss potential impacts on diagnostic refinement and treatment strategies.
Main Methods:
- Narrative review of current literature.
- Discussion of genetic mutations and immunological mechanisms.
- Synthesis of data on PP classification, clinical presentation, and management.
Main Results:
- PP pathogenesis involves innate immunity and the IL-36 axis, distinct from adaptive immunity in psoriasis vulgaris.
- Nosological aspects and therapeutic data for rare PP forms remain limited.
- Recent genetic and immunological discoveries are improving understanding of PP.
Conclusions:
- Understanding PP pathogenesis is evolving due to genetic and immunological research.
- Further research is needed to address diagnostic and therapeutic challenges in PP.
- Advances may lead to improved diagnostic criteria and treatment options for pustular psoriasis.
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