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Selectins

Selectins

Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...

Chemotaxis and Direction of Cell Migration

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...

Cell Adhesion Molecules - Types and Functions

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved...

Types of Signaling Molecules

Types of Signaling Molecules

In multicellular organisms, many molecules transmit signals between cells to pass information. These signals vary in complexity and include small peptides, nucleotides, steroids, fatty acid derivatives, and dissolved gases such as nitric oxide. Some signaling molecules diffuse through the plasma membrane to act locally between neighboring cells or travel long distances. Others remain attached to the cell surface, transmitting information to other cells only when they make contact. In some...

Cell Adhesion in Plants

Cell Adhesion in Plants

Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...

Cell Migration

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.

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Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling

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Natural Compounds as Target Biomolecules in Cellular Adhesion and Migration: From Biomolecular Stimulation to

Beatrix Péter¹, Imre Boldizsár^2,3, Gábor M Kovács^2,4

¹Nanobiosensorics Group, Research Centre for Energy Research, Institute for Technical Physics and Materials Science, Konkoly-Thege u 29-33, 1120 Budapest, Hungary.

|December 24, 2021

Summary

Natural compounds from plants and fungi offer anti-inflammatory and anticancer benefits by influencing cell adhesion and migration. New label-free methods enhance the screening of these bioactive metabolites for faster drug discovery.

Keywords:

CAM SARS-CoV-2 biosensors cell adhesion integrin isolation movement natural compound preparation viability

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Area of Science:

Pharmacology
Biochemistry
Cell Biology

Background:

Plants and fungi produce bioactive metabolites with potential health benefits, including anti-inflammatory and anticancer properties.
These natural compounds may exert their effects by modulating cellular adhesion and migration pathways.
Understanding these mechanisms is crucial for developing novel therapeutic strategies.

Purpose of the Study:

To review evidence on how natural metabolites influence cellular adhesion and migration.
To systematize knowledge on the mechanisms of action and gene expression effects of these compounds.
To explore novel screening methods for natural products and their application in viral infections like SARS-CoV-2.

Main Methods:

Systematic review and classification of recent studies on natural compounds affecting cellular adhesion and movement.
Characterization of active substances based on their organismal origin (plants, fungi, animals).
Summary of evidence for mechanisms involving signaling pathways and direct receptor inactivation.

Main Results:

Natural metabolites from plants and fungi influence cellular adhesion and migration through various mechanisms.
These compounds can directly inactivate cell adhesion receptors and affect gene expression.
Recent studies show potential for natural extracts in SARS-CoV-2 treatment by inhibiting viral adhesion and entry.

Conclusions:

Natural compounds represent a promising source for anti-inflammatory and anticancer drugs.
Label-free screening methods offer faster and more quantitative approaches for identifying bioactive metabolites.
Further research into natural products could lead to new therapeutic interventions for various diseases, including viral infections.