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Tissue Engineering of the Urethra: From Bench to Bedside
Dusan Pastorek1, Martina Culenova2,3, Maria Csobonyeiova4
1Department of Urology, University Hospital Bratislava, Pazitkova 4, 821 01 Bratislava, Slovakia.
Biomedicines
|December 24, 2021
Summary
Tissue engineering (TE) offers a promising solution for urethral strictures, but clinical application remains slow. Further research and collaboration are needed for wider adoption of TE in urethral reconstruction.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Urology
Background:
- Urethral strictures are a significant cause of morbidity, necessitating advanced treatment strategies.
- Tissue engineering (TE) presents a promising avenue for repairing or replacing damaged urethral tissues.
- Despite extensive preclinical success, clinical translation of TE for urethral repair has lagged.
Purpose of the Study:
- To systematically review the clinical applications of TE constructs for urethral repair over the past three decades.
- To identify challenges and opportunities for advancing TE in clinical urethral reconstruction.
Main Methods:
- Systematic literature review of clinical studies on TE for urethral repair.
- Analysis of data spanning the last 30 years.
Main Results:
- TE constructs demonstrate promise and effectiveness in preclinical settings for urethral repair.
- Clinical adoption of TE for urethral reconstruction faces significant hurdles.
- A substantial gap exists between preclinical TE advancements and clinical implementation.
Conclusions:
- The TE approach holds significant potential for urethral repair and reconstruction.
- Addressing issues in trial design, inter-group collaboration, and centralization is crucial for TE commercialization and routine clinical use.
- Enhanced cooperation and strategic planning are vital to overcome barriers to widespread clinical adoption of TE in urology.
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