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Complement and Coagulation System Crosstalk in Synaptic and Neural Conduction in the Central and Peripheral Nervous

Shani Berkowitz1,2, Joab Chapman1,2,3,4, Amir Dori1,2,5

  • 1Department of Neurology, The Chaim Sheba Medical Center, Ramat Gan 5266202, Israel.

Biomedicines
|December 24, 2021
PubMed

Insights

The complement and coagulation systems defend the body and interact within the nervous system. Modulating their crosstalk may offer new treatments for neuroinflammation.

Area of Science:

  • Neuroscience
  • Immunology
  • Hematology

Background:

  • Complement and coagulation systems are vital for bodily defense.
  • These systems share activation pathways and exhibit crosstalk.
  • Both systems have components within the central and peripheral nervous systems.

Purpose of the Study:

  • To review the roles of complement and coagulation in the CNS and PNS.
  • To explore the crosstalk between these systems in neuroinflammation.
  • To discuss potential therapeutic strategies targeting this crosstalk.

Main Methods:

  • Literature review of current evidence.
  • Analysis of physiological and pathophysiological roles.
  • Exploration of neuroinflammatory mechanisms.

Main Results:

  • Complement and coagulation influence neuronal development and synaptic plasticity.
  • Upregulated factors in these systems modulate synaptic transmission and neuronal conduction during disease.
  • Significant crosstalk exists between complement and coagulation in neuroinflammatory contexts.

Conclusions:

  • The complement and coagulation systems play critical roles in nervous system function and dysfunction.
  • Their interplay contributes to neuroinflammation, affecting synaptic transmission and neuronal conduction.
  • Targeting the crosstalk between complement and coagulation presents a promising therapeutic avenue for CNS and PNS disorders.

Keywords:
C1qC3neuroinflammationnode of Ranvierstrokesynaptic transmissionthrombin

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