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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
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Characterization and Functional Prediction of Bacteria in Ovarian Tissues
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Intestinal Microbiota in Postmenopausal Breast Cancer Patients and Controls.

Romy Aarnoutse1,2, Lars E Hillege1,2, Janine Ziemons1,2

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This study found no significant differences in gut microbiota between breast cancer patients and controls. However, specific bacteria were more abundant in patients receiving adjuvant treatment, possibly due to antibiotics.

Keywords:
breast neoplasmfaecesgut microbiotamicrobiomeoestrogen receptor positivepost menopause

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Area of Science:

  • Microbiome research
  • Oncology
  • Gastroenterology

Background:

  • Intestinal microbiota plays a role in carcinogenesis.
  • Evidence suggests gut bacteria influence breast cancer development.
  • Further investigation into the role of intestinal microbiota in breast cancer is needed.

Purpose of the Study:

  • To identify differences in intestinal microbiota between postmenopausal breast cancer patients and controls.
  • To compare microbiota composition in relation to treatment regimens.

Main Methods:

  • Prospective cohort study comparing 81 postmenopausal breast cancer patients and 67 controls.
  • Faecal samples analyzed using 16S rRNA V4 gene amplicon sequencing.
  • Microbiota richness, diversity, and composition were assessed.

Main Results:

  • No significant differences in overall microbiota richness, diversity, or community structure between patients and controls.
  • Significant differences in microbial community structure observed between patients receiving adjuvant treatment, neoadjuvant treatment, and controls at phylum and genus levels.
  • Increased abundance of Dialister and Veillonellaceae in patients scheduled for adjuvant treatment compared to neoadjuvant treatment.

Conclusions:

  • Overall intestinal microbiota composition is not significantly different between postmenopausal breast cancer patients and controls.
  • The observed increase in Dialister and Veillonellaceae in patients receiving adjuvant treatment may be attributed to prophylactic antibiotic use.
  • Antibiotic use may confound the assessment of microbiota differences in breast cancer patients.