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Decreased Resting-State Functional Complexity in Elderly with Subjective Cognitive Decline.

Huangjing Ni1,2, Zijie Song1, Lei Liang1

  • 1School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing 210003, China.

Entropy (Basel, Switzerland)
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Summary
This summary is machine-generated.

New brain entropy measure, amplitude-aware permutation entropy (AAPE), detects subtle differences in brain activity for individuals with subjective cognitive decline (SCD). Lower complexity in SCD may indicate early cognitive impairment, aiding Alzheimer's disease (AD) detection.

Keywords:
amplitude-aware permutation entropybrain dynamicscomplexityshort time series analysissubjective cognitive decline

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Cognitive Science

Background:

  • Subjective cognitive decline (SCD) indicates elevated risk for Alzheimer's disease (AD).
  • Resting-state functional MRI (fMRI) measures blood-oxygen-level-dependent (BOLD) signals to assess neural activity.
  • Early detection of cognitive changes in SCD is crucial for timely intervention.

Purpose of the Study:

  • To investigate if nonlinear complexity of BOLD signals can differentiate between SCD and normal aging.
  • To explore the neuropsychological implications of altered brain signal complexity in SCD.
  • To introduce and validate amplitude-aware permutation entropy (AAPE) as a novel measure of brain entropy.

Main Methods:

  • Utilized resting-state fMRI to acquire BOLD signals from participants.
  • Applied amplitude-aware permutation entropy (AAPE) to quantify BOLD signal complexity across brain regions defined by the Brainnetome atlas.
  • Compared brain entropy measures between individuals with SCD and healthy controls.

Main Results:

  • AAPE successfully identified subtle differences in brain complexity between SCD and normal aging groups.
  • The SCD group exhibited significantly reduced brain complexity in specific regions, including the superior temporal gyrus, inferior parietal lobule, postcentral gyrus, and insular gyrus.
  • Lower complexity in SCD correlated with poorer cognitive performance, suggesting potential subtle cognitive impairment.

Conclusions:

  • The novel AAPE measure is effective and sensitive for detecting altered brain entropy in SCD.
  • Reduced brain complexity in specific cortical regions may serve as a potential neuroimaging biomarker for early changes associated with Alzheimer's disease risk.
  • AAPE offers a promising tool for the early detection and characterization of cognitive changes in individuals with SCD.