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Network Dynamics in Elemental Assimilation and Metabolism.

Austen Curtin1, Christine Austin1, Alessandro Giuliani2

  • 1Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1057, New York, NY 10029, USA.

Entropy (Basel, Switzerland)
|December 24, 2021
PubMed
Summary
This summary is machine-generated.

Lead exposure disrupts essential element metabolism during development. This study used advanced analysis to reveal how lead affects nutrient integration and metabolic network connectivity in children.

Keywords:
elemental metabolismenvironmental exposuresgraph theorynetwork analysisrecurrence quantification analysis

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Area of Science:

  • Environmental Health Sciences
  • Systems Biology
  • Developmental Toxicology

Background:

  • Human development involves complex elemental metabolism, influenced by both essential and toxic elements.
  • Physiological processes exhibit non-linear dynamics, yet few biomarkers are analyzed as dynamical systems.
  • Understanding elemental integration dynamics is crucial for assessing developmental health impacts.

Purpose of the Study:

  • To reconstruct longitudinal elemental exposure profiles during prenatal and early postnatal development.
  • To characterize elemental integration dynamics and metabolism using systems-based approaches.
  • To investigate the impact of lead exposure on essential element metabolism and network connectivity.

Main Methods:

  • Laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) for elemental profiling.
  • Cross-recurrence quantification analysis (CRQA) to analyze dynamical system interactions.
  • Graph theory to model and analyze elemental metabolism networks.

Main Results:

  • Lead exposure was shown to perturb the metabolism of essential elements.
  • High lead exposure significantly altered global metabolic network connectivity, increasing element degree magnitude.
  • Specific essential elements, zinc and magnesium, exhibited reduced network metrics under high lead exposure.

Conclusions:

  • This study introduces a novel dynamical systems approach to studying elemental metabolism in development.
  • Lead exposure dysregulates the integration and metabolism of essential elements, impacting network dynamics.
  • Findings highlight the importance of assessing toxicant effects on complex metabolic networks during critical developmental periods.