Delayed type hypersensitivity responses to the Qa-Tla region of the mouse major histocompatibility complex

We have elicited a small but significant delayed-type hypersensitivity response against the Qa-Tla region of H-2 following immunisation of C57BL/6 mice with cells from the congenic strain C57BL/6.Tlaa. Optimal responses were detected 14 days after immunisation with 10-40 X 10(6) cells. The significance of delayed type hypersensitivity to Qa-Tla is discussed in relation to the genetic loci which map to this region.