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Impact of Carbon Fluoroxide Nanoparticles on Cell Proliferation
Alain Géloën1, Gauhar Mussabek2,3,4, Alexander Kharin1,4
1UMR Ecologie Microbienne Lyon (LEM), CNRS 5557, INRAE 1418, VetAgro Sup, Research Team "Bacterial Opportunistic Pathogens and Environment" (BPOE), Université Claude Bernard Lyon 1, 69622 Villeurbanne, France.
Abstract:
Cytotoxicity of fluorescent carbon fluoroxide (CFO) nanoparticles (NPs) was studied in a label-free manner on several cancer and non-cancer cell lines. A direct cytotoxic effect of the CFO NPs was clearly observed by a suppression of cell proliferation. The real-time measurement of cell activities allowed to quantify the impact of the uptaken NPs on cell proliferation and after washout of the NPs from the cell culture medium. The results show more toxic effects of the CFO NPs on cancer than on non-cancer cell lines. The notion of NPs biocompatibility must be related to a maximum concentration value of the NPs acceptable for a given cell type. Furthermore, the cytotoxicity effects of NPs should be studied not only during their direct exposure to cells but also after their washout from the culture medium.
