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Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

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Potentially Bioactive Fungus Mediated Silver Nanoparticles.

Abu Baker1, Sana Iram2, Asad Syed3

  • 1Nanomedicine & Nanobiotechnology Lab, Department of Biosciences, Integral University, Lucknow 226026, India.

Nanomaterials (Basel, Switzerland)
|December 24, 2021
PubMed
Summary

This study synthesized novel silver nanoparticles (F-AgNPs) from a unique fungus, demonstrating potent antimicrobial and anticancer activities. These F-AgNPs show promise as a new therapeutic agent against drug-resistant bacteria and lung cancer cells.

Keywords:
AgNPSantibacterialantibiofilmanticancerfungus

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Area of Science:

  • Nanotechnology
  • Mycology
  • Biotechnology

Background:

  • Fungal metabolites are a valuable source of therapeutic compounds.
  • Novel fungal strains offer potential for developing new bioactive agents.
  • Silver nanoparticles (AgNPs) possess broad-spectrum antimicrobial and anticancer properties.

Purpose of the Study:

  • To synthesize silver nanoparticles (F-AgNPs) using a newly identified fungus (Alternaria sp.).
  • To evaluate the antimicrobial, antifungal, antibiofilm, and anticancer activities of the synthesized F-AgNPs.
  • To characterize the physical and chemical properties of F-AgNPs.

Main Methods:

  • Biosynthesis of F-AgNPs using Alternaria sp. hypha extract.
  • Characterization using UV-Vis, zeta potential, DLS, XRD, TEM, HR-TEM, and FTIR.
  • Antimicrobial activity testing against MDR bacteria (MIC50).
  • Antifungal activity testing against pathogenic fungi.
  • Biofilm inhibition assays.
  • Anticancer activity testing against A549 lung cancer cells and normal BEAS-2 cells.

Main Results:

  • F-AgNPs were quasi-spherical, ~15 nm in size, crystalline (cubic phase), and stable (zeta potential -20.3 mV).
  • F-AgNPs exhibited significant activity against MDR bacteria (Staphylococcus aureus, Escherichia coli) and pathogenic fungi.
  • Effective inhibition of bacterial biofilm formation (16.66–64.81%).
  • Selective anticancer activity against A549 cells (IC50 21.6 µg/mL) with no significant toxicity to normal BEAS-2 cells.
  • Mechanism involves mitochondrial dysfunction, ROS generation, and induction of programmed cell death.

Conclusions:

  • Biosynthesized F-AgNPs from Alternaria sp. demonstrate potent and selective antimicrobial and anticancer properties.
  • F-AgNPs represent a promising candidate for developing novel therapeutic agents against infectious diseases and lung cancer.
  • The study highlights the potential of fungal-derived nanomaterials in nanomedicine.