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Novel Perspectives towards RNA-Based Nano-Theranostic Approaches for Cancer Management
Rabia Arshad1, Iqra Fatima2, Saman Sargazi3
1Faculty of Pharmacy, University of Lahore, Lahore 45320, Pakistan.
Nanomaterials (Basel, Switzerland)
|December 24, 2021
Summary
Nanoparticles and nano-biosensors offer advanced cancer diagnosis and targeted treatment. RNA nanotechnology, using small interfering RNAs (siRNA), shows promise for personalized cancer therapies and inducing cancer cell death.
Area of Science:
- Oncology
- Nanotechnology
- Biomedical Engineering
Background:
- Early cancer diagnosis is crucial but limited by traditional methods.
- Multi-functionalized nanoparticles (NPs) and nano-biosensors enhance cancer detection and targeted treatment.
- Ligands on NPs target cancer tissues with over-expressed markers.
Purpose of the Study:
- To review the latest advances in RNA nanotechnology for cancer diagnosis and treatment.
- To highlight the role of multi-functionalized NPs and nano-biosensors in personalized cancer therapy.
- To discuss RNA interference (RNAi) strategies using small interfering RNAs (siRNAs).
Main Methods:
- Modification of molecular genetics for personalized treatments.
- Utilizing small interfering RNAs (siRNAs) to target overexpressed genes in cancers.
- Conjugating RNA with nanomaterials for targeted delivery and action.
Main Results:
- RNA-conjugated nanomaterials enable focused diagnosis and targeted delivery to specific tissues.
- RNA therapies, particularly siRNA, are effective against breast, colon, gastric, cervical, and hepatocellular cancers.
- Nanotechnology facilitates personalized and targeted cancer treatments via RNA interference.
Conclusions:
- RNA nanotechnology represents a gold standard for preventing tumors through precise diagnosis and treatment.
- Targeted delivery of RNA-based therapies via nanomaterials can induce programmed cancer cell death.
- Advancements in RNA nanotechnology offer new avenues for personalized and effective cancer care.
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