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Bioavailability Enhancement: Drug Permeability Enhancement

Bioavailability Enhancement: Drug Permeability Enhancement

Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

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Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

Lipid-Based Nanovesicular Drug Delivery Systems.

Tania Limongi¹, Francesca Susa¹, Monica Marini¹

¹Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy.

Nanomaterials (Basel, Switzerland)

|December 24, 2021

Summary

Lipid nanovesicular carriers offer advanced drug delivery solutions, overcoming challenges like poor solubility and biological barriers. This review explores various types of these nanocarriers for improved therapeutic outcomes.

Keywords:

catanionic vesicles ethosomes extracellular vesicles lipid vesicles niosomes pharmacosomes phytosomes proniosomes transferosomes ufasomes

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Area of Science:

Pharmaceutical Sciences
Nanotechnology
Biochemistry

Background:

Drug design requires reliable pharmacokinetics and tolerability.
Nanotechnology offers advanced solutions for drug delivery optimization.
Lipid nanovesicular carriers address challenges such as insolubility and biological barrier penetration.

Purpose of the Study:

To review the structure, composition, and applications of lipid nanovesicular carriers.
To highlight the role of nanotechnologies in pharmaceutical development.
To discuss various types of lipid nanovesicular systems for drug delivery.

Main Methods:

Literature review of nanotechnologies in drug delivery.
Analysis of lipid nanovesicular carrier structures and compositions.
Examination of drug delivery applications, including overcoming biological barriers.

Main Results:

Lipid nanovesicular carriers demonstrate significant potential in drug formulation.
Various types of lipid nanovesicles (niosomes, ethosomes, etc.) are effective drug delivery systems.
These carriers improve drug solubility, stability, and targeted delivery.

Conclusions:

Lipid nanovesicular carriers are crucial for advancing drug delivery systems.
Further research into these nanocarriers can lead to improved therapeutic efficacy.
Nanotechnology-based drug delivery holds great promise for future medicine.