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Related Experiment Video

Updated: Oct 9, 2025

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs
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High Sensitivity Surface Plasmon Resonance Sensor Based on Periodic Multilayer Thin Films.

Haoyuan Cai1,2,3, Shihan Shan1,2,3, Xiaoping Wang1,2,3

  • 1Ocean College, Zhejiang University, Zhoushan 316021, China.

Nanomaterials (Basel, Switzerland)
|December 24, 2021
PubMed
Summary

This study introduces a novel silver and TiO2 thin film biosensor for enhanced sensitivity. Optimized using a genetic algorithm, it achieves significantly higher performance than conventional sensors for various applications.

Keywords:
SPR sensorgenetic algorithmhigh sensitivitymultilayer thin film

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Surface Plasmon Resonance (SPR) biosensors are crucial for high-sensitivity detection.
  • Oxidation of silver (Ag) films can degrade biosensor performance.
  • Enhancing the electromagnetic field within the sensor structure improves sensitivity.

Purpose of the Study:

  • To propose and optimize a novel SPR biosensor structure using alternate layers of silver (Ag) and titanium dioxide (TiO2) thin films.
  • To enhance the sensitivity and stability of SPR biosensors.
  • To investigate the underlying physical mechanisms for the improved performance.

Main Methods:

  • Fabrication of alternate Ag/TiO2 thin film layers.
  • Optimization of the proposed biosensor structure using a Genetic Algorithm (GA).
  • Analysis of the sensor's performance and field enhancement using the Finite Difference Time Domain (FDTD) method.

Main Results:

  • The optimized Ag/TiO2 biosensor demonstrated a maximum angular sensitivity of 384°/RIU at a refractive index of 1.3425.
  • This sensitivity is approximately 3.12 times greater than conventional Ag-based biosensors.
  • FDTD analysis confirmed enhanced evanescent fields at the top layer, contributing to ultra-sensitivity.

Conclusions:

  • The proposed Ag/TiO2 thin film structure offers a promising approach for developing highly sensitive SPR biosensors.
  • This structure effectively prevents Ag film oxidation and enhances sensor performance.
  • The developed biosensor is suitable for applications in chemical detection, clinical diagnostics, and biological examination.