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Summary
Brucella melitensis infection rarely affects the central nervous system (CNS). Combination antibiotic therapy for 6-8 weeks effectively treated acute brucella meningitis in three patients.
Area of Science:
- Infectious Diseases
- Neurology
- Public Health
Background:
- Brucella melitensis is endemic in Saudi Arabia.
- Central nervous system (CNS) involvement in Brucella infections is uncommon.
Observation:
- Three patients presented with acute brucella meningitis.
- All patients had a history of potential exposure to Brucella.
- Diagnosis was confirmed via blood cultures isolating Brucella species.
Findings:
- Cerebrospinal fluid analysis showed lymphocytic pleocytosis, high protein, and low glucose.
- Treatment involved combinations of co-trimoxazole, doxycycline, or rifampicin.
- All patients responded well to treatment with no recurrences.
Implications:
- Combination antibiotic therapy (2-3 drugs) for 6-8 weeks is effective for CNS brucellosis.
- Early diagnosis and treatment are crucial for favorable outcomes.
- This highlights the importance of considering Brucella meningitis in endemic areas with neurological symptoms.