Zapotin, a Polymethoxyflavone, with Potential Therapeutic Attributes.
Jakub W Strawa1, Katarzyna Jakimiuk1, Michał Tomczyk1
1Department of Pharmacognosy, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Białystok, ul. Mickiewicza 2a, 15-230 Białystok, Poland.
International Journal of Molecular Sciences
|December 24, 2021
Summary
Polymethoxyflavones (PMFs), like zapotin from citrus peels, show significant therapeutic potential. This review details zapotin
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Medicinal Chemistry
Background:
- Traditional medicine extensively utilizes plants.
- Polymethoxyflavones (PMFs) are a class of natural polyphenols found in flavonoids.
- Zapotin, a PMF primarily found in citrus peels, has a unique chemical structure.
Purpose of the Study:
- To clarify the chemical structure of zapotin.
- To discuss the bio-inspired synthesis of zapotin.
- To review the isolation, characterization, and purification of PMFs.
Main Methods:
- Literature review of available data.
- Analysis of chromatographic methods for PMF isolation and purification.
- Examination of studies on zapotin's biological activities and metabolism.
Main Results:
- Zapotin's structure determination and bio-inspired synthesis are detailed.
- Various chromatographic techniques are assessed for PMF purification.
- Zapotin exhibits antidepressant-like, anticancer, antifungal, and antioxidant properties.
Conclusions:
- Zapotin is a promising curative agent, particularly as a chemopreventive factor.
- Metabolism studies (ADMET) support zapotin's therapeutic potential.
- Further research into PMFs like zapotin is warranted for drug development.
