Related Experiment Video

Updated: Oct 9, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.4K

Proteomic Studies of Blood and Vascular Wall in Atherosclerosis

Ekaterina Mikhailovna Stakhneva1, Evgeniia Vitalievna Striukova1, Yulia Igorevna Ragino1

  • 1The Institute of Internal and Preventive Medicine, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, St. B. Bogatkova 175/1, 630089 Novosibirsk, Russia.

International Journal of Molecular Sciences
|December 24, 2021
PubMed

Insights

Proteomic studies reveal potential biomarkers for early diagnosis of atherosclerotic cardiovascular diseases. Analyzing protein profiles in the vascular wall aids in detecting atherosclerosis and its complications.

Area of Science:

  • Cardiovascular Medicine
  • Proteomics
  • Biomarker Discovery

Background:

  • Atherosclerotic cardiovascular diseases (ASCVDs) pose a significant diagnostic challenge, especially before clinical manifestation.
  • Early detection of atherosclerotic plaques is crucial for effective intervention and management.
  • Proteomic studies offer a powerful approach to identify novel diagnostic and prognostic markers for ASCVDs.

Purpose of the Study:

  • To review and analyze the role of proteomic studies in understanding atherosclerotic cardiovascular diseases.
  • To identify potential proteomic biomarkers for various forms of atherosclerosis, including coronary heart disease, acute coronary syndrome, myocardial infarction, and carotid artery atherosclerosis.
  • To explore the proteomic profile of the vascular wall in the context of atherosclerosis.

Main Methods:

  • Comprehensive literature review of proteomic studies related to atherosclerotic cardiovascular diseases.
  • Analysis of research on proteomic biomarkers for coronary heart disease, coronary atherosclerosis, acute coronary syndrome, myocardial infarction, and carotid artery atherosclerosis.
  • Examination of proteomic data from the vascular wall in atherosclerotic conditions.

Main Results:

  • Proteomic analysis has identified numerous proteins associated with the development and progression of atherosclerosis.
  • Specific protein expression patterns and concentrations in the vascular wall are linked to the pathological process.
  • Several potential proteomic biomarkers have been proposed for early diagnosis and risk stratification of ASCVDs.

Conclusions:

  • Proteomic studies are instrumental in unraveling the complex molecular mechanisms underlying atherosclerosis.
  • Analysis of vascular wall proteomes can lead to the discovery of novel diagnostic biomarkers.
  • Advancements in proteomic technologies hold promise for developing innovative diagnostic strategies for atherosclerosis and its complications.

Keywords:
atherosclerosisbiomarkersmass spectrometryproteomics

More Related Videos

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 7, 2013

14.0K
Quantification of Atherosclerosis in Mice06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

38.7K

Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
157
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
81
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
251
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
390
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
62
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
330