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Updated: Oct 9, 2025

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
Targeting Non-Replicating Mycobacterium tuberculosis and Latent Infection: Alternatives and Perspectives
Anna Egorova1, Elena G Salina1,2, Vadim Makarov1
1The Federal Research Centre "Fundamentals of Biotechnology" of the Russian Academy of Sciences (Research Center of Biotechnology RAS), 119071 Moscow, Russia.
Abstract:
Latent tuberculosis infection (LTBI) represents a major challenge to curing TB disease. Current guidelines for LTBI management include only three older drugs and their combinations-isoniazid and rifamycins (rifampicin and rifapentine). These available control strategies have little impact on latent TB elimination, and new specific therapeutics are urgently needed. In the present mini-review, we highlight some of the alternatives that may potentially be included in LTBI treatment recommendations and a list of early-stage prospective small molecules that act on drug targets specific for Mycobacterium tuberculosis latency.
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