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Related Experiment Videos

Complement activation during major operations with or without cardiopulmonary bypass.

E Fosse, T E Mollnes, B Ingvaldsen

    The Journal of Thoracic and Cardiovascular Surgery
    |June 1, 1987
    PubMed
    Summary
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    Extracorporeal circulation activates the terminal complement pathway during major surgeries, impacting granulocyte counts. Monitoring both initial and terminal complement activation is crucial for understanding surgical pathophysiology.

    Area of Science:

    • Cardiovascular Surgery
    • Immunology
    • Complement System Biology

    Background:

    • Major surgeries involve complex physiological responses.
    • The complement system plays a role in inflammation and immune response.
    • Understanding complement activation during surgery is vital for patient outcomes.

    Purpose of the Study:

    • To investigate complement activation during different surgical procedures.
    • To assess the impact of extracorporeal circulation on complement pathways.
    • To correlate complement activation with granulocyte response.

    Main Methods:

    • Measured plasma concentrations of C3dg and terminal complement complex.
    • Quantified granulocyte (polymorphonuclear neutrophils) counts.
    • Compared complement activation across aorta-coronary bypass, abdominal aneurysmectomy, and thoracotomy groups.

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    Main Results:

    • Terminal complement complex increased significantly with extracorporeal circulation, alongside a granulocyte drop.
    • C3dg levels rose during both extracorporeal circulation and abdominal aneurysmectomy, suggesting broader C3 activation.
    • Thoracotomy without synthetic material showed no complement activation but increased granulocytes.

    Conclusions:

    • Extracorporeal circulation specifically activates the terminal complement pathway.
    • Major surgeries, beyond extracorporeal circulation, can influence C3 activation.
    • Comprehensive complement assessment, including initial and terminal pathways, is recommended during major operations.