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Updated: Oct 9, 2025

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
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Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

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Comparative Effect of Antihypertensive Drugs in Improving Arterial Stiffness in Hypertensive Adults (RIGIPREV Study).

Iván Cavero-Redondo1,2, Alicia Saz-Lara1, Luis García-Ortiz3,4

  • 1Health and Social Research Center, Universidad de Castilla-La Mancha, 16171 Cuenca, Spain.

International Journal of Environmental Research and Public Health
|December 24, 2021
PubMed

Insights

This review compares how different antihypertensive drugs affect arterial stiffness in hypertension patients. It aims to guide healthcare professionals in choosing treatments that lower both blood pressure and arterial stiffness.

Area of Science:

  • Cardiology
  • Pharmacology
  • Hypertension Research

Background:

  • Arterial stiffness is intrinsically linked to hypertension, acting as both a cause and consequence.
  • Antihypertensive medications may influence arterial stiffness, suggesting a dual role in treatment.
  • Optimizing hypertension management requires considering both blood pressure and arterial stiffness.

Purpose of the Study:

  • To systematically review and compare the effects of various antihypertensive drug classes on reducing arterial stiffness.
  • To provide evidence-based guidance for clinicians on selecting antihypertensive therapies.

Main Methods:

  • A comprehensive literature search across major databases (MEDLINE, EMBASE, Cochrane, Web of Science).
  • Inclusion of randomized clinical trials evaluating antihypertensive interventions and arterial stiffness measurements.
  • A frequentist network meta-analysis to compare the efficacy of different drug classes.

Main Results:

  • Study findings will be published in a peer-reviewed journal.
  • The analysis will quantify the comparative effectiveness of antihypertensive drugs on arterial stiffness reduction.

Conclusions:

  • This study will offer critical evidence for healthcare professionals regarding antihypertensive drug efficacy.
  • The research will inform treatment strategies by analyzing drug effectiveness for both blood pressure and arterial stiffness.

Keywords:
antihypertensive drugsarterial stiffnesshypertensive adultsnetwork meta-analysis

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