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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Correlation Between Changes in Lamina Cribrosa Structure and Visual Field in Primary Open-Angle Glaucoma.

Ahmed El Basty1, Raouf Gaber1, Ahmed Elmaria1

  • 1Department of Ophthalmology, Tanta University, Tanta, Gharbeya Province, Egypt.

Clinical Ophthalmology (Auckland, N.Z.)
|December 24, 2021
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Summary

Enhanced depth imaging (EDI) revealed that anterior lamina cribrosa surface depth and prelaminar neural tissue (PLNT) thickness/area correlate with visual field severity in primary open-angle glaucoma (POAG). EDI-OCT aids in monitoring POAG structural changes.

Keywords:
EDIPLNT thicknessbiomarkerblindnesslamina cribrosa

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Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Optical Coherence Tomography

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • Assessing structural changes in the optic nerve head (ONH) and lamina cribrosa (LC) is crucial for POAG management.
  • Enhanced depth imaging optical coherence tomography (EDI-OCT) offers high-resolution visualization of the ONH and LC.

Purpose of the Study:

  • To investigate the correlation between lamina cribrosa (LC) structural changes visualized by enhanced depth imaging (EDI) and the severity of visual field (VF) defects in primary open-angle glaucoma (POAG).

Main Methods:

  • A prospective cross-sectional study included 52 glaucomatous eyes from 28 POAG patients and 40 normal eyes from 20 controls.
  • POAG patients were stratified into mild-to-moderate (MD ≤ 12 dB) and severe (MD ≥ 12 dB) visual field loss groups based on standard automated perimetry (SAP).
  • Lamina cribrosa (LC) thickness, area, anterior surface depth, and prelaminar neural tissue (PLNT) thickness and area were measured using EDI-OCT.

Main Results:

  • No significant differences were found in LC thickness or area between POAG and control groups.
  • No significant correlation was observed between mean deviation (MD) and LC thickness or area (P > 0.395).
  • A significant correlation was found between MD and anterior LC surface depth (P=0.002), and between MD and PLNT thickness/area (P < 0.023).

Conclusions:

  • Anterior lamina cribrosa surface depth and prelaminar neural tissue (PLNT) dimensions are significantly correlated with visual field severity in POAG.
  • EDI-OCT is a valuable tool for detecting structural changes in the ONH and LC.
  • EDI-OCT should be considered for routine monitoring of patients with POAG.