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The Degree of Plasma Oxidized Low-Density Lipoprotein Level Decrease Is Related to Clinical Outcomes for Patients
Xiaoli Yang1, Wenbo Sun1, Duanlu Hou1
1Department of Neurology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Disease Markers
|December 24, 2021
Summary
A significant decrease in oxidized low-density lipoprotein (oxLDL) levels is linked to better recovery and long-term outcomes in acute ischemic stroke patients. This reduction, however, did not correlate with acute infarct volume.
Area of Science:
- Cardiovascular Research
- Neurology
- Biochemistry
Background:
- Atherosclerosis-related ischemic stroke poses significant health challenges.
- Oxidized low-density lipoprotein (oxLDL) is implicated in atherosclerotic plaque development and instability.
- Understanding biomarkers that predict stroke outcomes is crucial for patient management.
Purpose of the Study:
- To investigate the association between the reduction in plasma oxLDL levels and clinical outcomes in patients experiencing acute ischemic stroke.
- To determine if changes in oxLDL levels correlate with stroke severity or infarct volume.
Main Methods:
- Prospective enrollment of 207 acute ischemic stroke patients within 3 days of onset.
- Measurement of plasma oxLDL levels at admission and before discharge.
- Assessment of stroke severity using NIHSS scores and infarct volume via DWI.
- Evaluation of neurological improvement and functional prognosis at discharge and 90 days, respectively.
- Logistic regression analysis to determine the relationship between oxLDL decrease and outcomes.
Main Results:
- Patients with a significant decrease in oxLDL levels showed higher rates of neurological improvement at discharge (55.07% vs. 14.49%) and favorable 90-day prognosis (91.30% vs. 55.07%) compared to those with mild decreases.
- Multivariable analysis confirmed that a greater oxLDL level decrease was significantly associated with improved neurological function at discharge (OR=7.92) and favorable 90-day prognosis (OR=7.46).
- No significant difference in acute infarct volume was observed between groups with varying degrees of oxLDL decrease, nor was there a significant correlation between oxLDL reduction and DWI infarct volume (rho=-0.03).
Conclusions:
- The degree of plasma oxLDL level decrease is a significant predictor of neurological improvement and favorable functional prognosis in patients with acute atherosclerosis-related ischemic stroke.
- Changes in oxLDL levels do not appear to be associated with infarct volume in the acute phase of ischemic stroke.
- Monitoring oxLDL level reduction may offer insights into stroke recovery potential.
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