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Evidence for Involvement of Nonclassical Pathways in the Protection From UV-Induced DNA Damage by Vitamin D-Related

Warusavithana Gunawardena Manori De Silva1, Jeremy Zhuo Ru Han1, Chen Yang1

  • 1Physiology, School of Medical Sciences and Bosch Institute University of Sydney Sydney NSW Australia.

JBMR Plus
|December 24, 2021
PubMed
Summary

Vitamin D compounds protect skin from UV damage by reducing DNA lesions. This photoprotective effect requires the vitamin D receptor and impacts cellular respiration and CREB phosphorylation, suggesting an anti-cancer role.

Keywords:
1α,25‐DIHYDROXYVITAMIN D3CREB PHOSPHORYLATIONERp57LUMISTEROLOXIDATIVE PHOSPHORYLATIONUV‐INDUCED DNA DAMAGEVITAMIN D RECEPTOR

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