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Protein Based Biomaterials for Therapeutic and Diagnostic Applications
Stanley Chu1, Andrew L Wang1,2,3, Aparajita Bhattacharya1,4
1Department of Chemical and Biomolecular Engineering, NYU Tandon School of Engineering, Brooklyn, NY, United States of America.
Progress in Biomedical Engineering (Bristol, England)
|December 24, 2021
Summary
Protein biomaterials offer advantages for delivering therapeutics due to their bioactivity and customizability. This review highlights advances in protein structures, assemblies, and responsive materials for advanced drug and cell delivery systems.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery
Background:
- Proteins are versatile macromolecules with inherent bioactivity and low immunogenicity, making them advantageous over synthetic materials.
- Proteins can be engineered via amino acid sequence modification and self-assembly into higher-order structures.
- Recent advances focus on protein-based biomaterials for enhanced therapeutic cargo delivery.
Purpose of the Study:
- To review recent advancements in protein-based biomaterials for therapeutic delivery.
- To explore the role of protein structural motifs and supramolecular assemblies in drug delivery.
- To discuss environmental responsiveness and theranostic applications of protein materials.
Main Methods:
- Review of literature on protein structural motifs (secondary structures) for therapeutic delivery.
- Analysis of supramolecular assemblies (fibers, nanoparticles, hydrogels) for cohesive engineered behavior.
- Examination of modifications for environmental responsiveness, including protein molecular robots and theranostic materials.
Main Results:
- Protein secondary structural motifs possess unique properties beneficial for therapeutic delivery.
- Engineered supramolecular assemblies demonstrate cohesive behavior for controlled cargo release.
- Protein materials are being modified for environmental responsiveness and theranostic applications.
Conclusions:
- Protein-based biomaterials represent a promising platform for advanced therapeutic delivery systems.
- Functionalization and self-assembly of proteins enable tailored material properties for specific applications.
- Emerging applications include protein molecular robots and theranostic agents for combined therapy and imaging.
