[A new hexenol glycoside from Buddleja officinalis]

Area of Science:

• Phytochemistry
• Natural Product Chemistry
• Pharmacognosy

Background:

• Buddleja officinalis is traditionally used in herbal medicine.
• Understanding its chemical composition is crucial for its medicinal applications.
• Previous research has identified some constituents, but a comprehensive analysis of flower bud compounds is needed.

Purpose of the Study:

• To isolate and identify chemical constituents from the flower buds of Buddleja officinalis.
• To characterize novel compounds and those previously unreported in the Buddleja genus or this specific plant.

Main Methods:

• Water extraction of Buddleja officinalis flower buds.
• Isolation of compounds using column chromatography.
• Structure elucidation through physicochemical properties and spectral data analysis.

Main Results:

• Eight compounds were successfully isolated and identified.
• A new 3-hexenol glycoside, (Z)-hex-3-en-1-ol-1-O-β-D-glucopyranosyl-(1→2)-[β-D-xylcopyranosyl-(1→6)]-β-D-glucopyranoside, was discovered.
• Ebracteatoside B, jasmonic acid-11-O-β-D-glucopyranoside, and vicenin-2 were isolated from the Buddleja genus for the first time.
• 6-hydroxyluteolin-7-O-β-D-glucopyranoside and luteolin-7-O-galacturonide were isolated from this plant for the first time.

Conclusions:

• The chemical profile of Buddleja officinalis flower buds is diverse.
• This study expands the known phytochemical database of Buddleja species.
• The identified compounds may contribute to the traditional medicinal properties of Buddleja officinalis.