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Clinical and Laboratory Factors Associated with Symptom Development in Asymptomatic COVID-19 Patients at the Time of

Hong Sang Oh1, Joon Ho Kim2, Myoung Lyeol Woo3

  • 1Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam, Korea.

Infection & Chemotherapy
|December 24, 2021
PubMed

Insights

Identifying early symptoms in asymptomatic COVID-19 patients is key for resource allocation during surges. A short exposure-diagnosis interval and abnormal AST levels may indicate symptom development in these cases.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Clinical Medicine

Background:

  • Efficient medical resource allocation is critical during COVID-19 surges.
  • Distinguishing asymptomatic cases is essential for managing healthcare capacity.

Purpose of the Study:

  • To identify clinical and epidemiological characteristics of asymptomatic COVID-19 patients.
  • To aid in early differentiation of asymptomatic individuals who may develop symptoms.

Main Methods:

  • Retrospective analysis of 66 asymptomatic COVID-19 patients diagnosed between January 27 and April 21, 2020.
  • Data collected from 13 healthcare facilities in Gyeonggi province, Korea.
  • Evaluation of epidemiologic and clinical information.

Main Results:

  • An exposure-diagnosis interval within 7 days was a characteristic finding.
  • Abnormal aspartate aminotransferase (AST) levels were identified as another key indicator.
  • These factors may predict symptom development in initially asymptomatic cases.

Conclusions:

  • Early identification of asymptomatic COVID-19 patients likely to develop symptoms can be aided by specific indicators.
  • This differentiation can help secure medical resources for mild to moderate COVID-19 cases during surges.
  • Further research can refine criteria for predicting symptom onset in asymptomatic individuals.

Keywords:
AsymptomaticCOVID-19Medical resource allocationSARS-CoV-2Symptom development

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