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FGF signalling facilitates cervical cancer progression.

Hiba-Tun-Noor Afshan Mahmood1, Elena Tomas Bort2, Anthony J Walker1

  • 1School of Life Sciences Pharmacy and Chemistry, Kingston University, Kingston upon Thames, UK.

The FEBS Journal
|December 24, 2021
PubMed
Summary

Fibroblast growth factor receptor (FGFR) signaling is associated with cervical cancer progression. Activating FGFR signaling promotes cell functions linked to invasive cervical cancer, suggesting FGFR as a therapeutic target.

Keywords:
FGFR signalingcervical cancermetastasis

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Area of Science:

  • Oncology
  • Molecular Biology
  • Gynecologic Oncology

Background:

  • Cervical cancer, often caused by human papillomavirus (HPV), has poorly understood molecular mechanisms.
  • Fibroblast growth factor receptor (FGFR) signaling is implicated in various cancers, but its role in cervical cancer is unclear.

Purpose of the Study:

  • To investigate the role and mechanisms of FGFR signaling in cervical cancer progression.
  • To analyze FGFR expression and function in cervical cancer cell lines.

Main Methods:

  • Bioinformatic analysis of cell line and patient data.
  • Expression profiling (mRNA and protein) of FGFRs and FGFs.
  • Functional assays involving FGFR activation in 2D and 3D cell cultures.

Main Results:

  • FGFR1b/c, FGFR2b/c, FGFR4, FGF2, FGF4, and FGF7 were expressed in cervical cancer cell lines.
  • FGFR1 and FGFR2 were found in the nucleus, suggesting potential transcription factor activity.
  • FGFR activation enhanced cell functions associated with invasive cervical cancer.

Conclusions:

  • FGFR signaling is linked to cervical cancer progression.
  • Nuclear FGFRs may play a role in cervical cancer pathogenesis.
  • Targeting FGFR signaling presents a potential therapeutic strategy for cervical cancer.