[Radiosurgery for recurrent glioblastoma].

Area of Science:

• Neuro-oncology
• Radiation Oncology
• Neurosurgery

Background:

• Recurrent glioblastoma has a poor prognosis despite standard treatments.
• Repeated radiotherapy is a key strategy for managing malignant glioma progression.
• Stereotactic irradiation has expanded options for repeated radiotherapy.

Purpose of the Study:

• To assess radiosurgery outcomes in recurrent glioblastoma patients.
• To identify factors influencing the effectiveness of radiosurgery for glioblastoma recurrence.

Main Methods:

• Radiosurgery was performed on 88 patients with recurrent glioblastoma (180 foci) between 2005 and 2021.
• Mean patient age was 42.8 years; mean time to re-irradiation was 12.7 months.
• Treatments involved a mean dose of 20 Gy to a mean volume of 2.4 cm³; median follow-up was 11.2 months.

Main Results:

• Repeated irradiation improved progression-free survival (PFS) and overall survival (OS) with low toxicity.
• Annual OS was 62.2%; median OS post-radiosurgery was 15.1 months.
• Local control was associated with doses ≥18 Gy and local recurrence (median PFS 9.1 months vs. 3.6 months for distant recurrence).

Conclusions:

• Dose-escalated radiosurgery (≥18 Gy) is effective for local treatment of recurrent glioblastoma.
• This approach enhances PFS and OS in patients with glioblastoma progression.
• Radiosurgery offers a viable option for managing glioblastoma relapse.