Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

911
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
911
Pain01:20

Pain

723
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
723
Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

139
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
139
Altered States of Awareness01:06

Altered States of Awareness

581
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
581
Nociception01:44

Nociception

30.4K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
30.4K
Psychosurgery01:30

Psychosurgery

127
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
127

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Production of an immunogenic trivalent poliovirus virus-like particle vaccine candidate in yeast using controlled fermentation.

NPJ vaccines·2026
Same author

Production of an immunogenic trivalent poliovirus virus-like particle vaccine candidate in yeast using controlled fermentation.

NPJ vaccines·2025
Same author

Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines.

Nature communications·2025
Same author

Pain tolerance and threshold in suicide attempters: A systematic review and meta-analysis.

Psychiatry research·2023
Same author

Production of antigenically stable enterovirus A71 virus-like particles in <i>Pichia pastoris</i> as a vaccine candidate.

The Journal of general virology·2023
Same author

Integrating Psychiatric Services in the Emergency Room to Improve Patient Care by Using Quality Improvement Methods.

The Journal of nervous and mental disease·2023

Related Experiment Video

Updated: Oct 8, 2025

Burn Injury-Induced Pain and Depression-Like Behavior in Mice
07:08

Burn Injury-Induced Pain and Depression-Like Behavior in Mice

Published on: September 29, 2021

3.3K

Altered physical pain processing in different psychiatric conditions.

Diane J Kim1, Julianne Mirmina1, Serah Narine1

  • 1Department of Psychiatry and Behavioral Sciences, Stony Brook University, Stony Brook, New York, USA.

Neuroscience and Biobehavioral Reviews
|December 24, 2021
PubMed
Summary

Patients with major depression often have a reduced pain threshold, while schizophrenia patients show widespread low pain sensitivity. Understanding these pain perception differences is crucial for improving patient care.

Keywords:
DepressionExperimental painPTSDPain perceptionSchizophrenia

More Related Videos

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
07:12

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Published on: January 21, 2020

7.9K
Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity
07:28

Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity

Published on: January 21, 2017

7.1K

Related Experiment Videos

Last Updated: Oct 8, 2025

Burn Injury-Induced Pain and Depression-Like Behavior in Mice
07:08

Burn Injury-Induced Pain and Depression-Like Behavior in Mice

Published on: September 29, 2021

3.3K
Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
07:12

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Published on: January 21, 2020

7.9K
Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity
07:28

Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity

Published on: January 21, 2017

7.1K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pain Research

Background:

  • Chronic pain is common in psychiatric disorders.
  • Pain sensitivity can be altered in conditions like depression and schizophrenia.
  • Existing research shows varied findings on pain perception in mental health conditions.

Purpose of the Study:

  • To review and synthesize findings on experimental pain sensitivity in major psychiatric disorders.
  • To identify patterns of altered pain perception across conditions including depression, schizophrenia, PTSD, bipolar disorder, and anxiety disorders.
  • To highlight the need for recognizing these sensory abnormalities in clinical practice.

Main Methods:

  • Conducted electronic literature searches for studies comparing experimental pain in psychiatric patients and controls.
  • Analyzed data from studies on major depression, bipolar disorder, PTSD, generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, and schizophrenia.
  • Synthesized findings regarding pain threshold, tolerance, and sensitivity across different pain stimuli.

Main Results:

  • Major depression studies (n=31) often showed reduced pain thresholds, except for ischemic pain (increased tolerance/sensitivity).
  • Schizophrenia studies (n=20) revealed a consistent pattern of low pain sensitivity.
  • PTSD studies (n=20) generally found no significant differences; bipolar disorder and anxiety disorder studies were limited, showing unclear trends.
  • Significant data variability was observed across studies.

Conclusions:

  • Psychiatric patients exhibit distinct abnormalities in pain perception.
  • Awareness of these altered pain sensitivities is essential for effective screening.
  • Addressing physical comorbidities linked to pain perception can improve patient outcomes, quality of life, and life expectancy.