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Context-dependent transcriptional regulations of YAP/TAZ in cancer

Yibo Guo1, Juan Luo1, Hailin Zou1

  • 1Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, Guangdong, People's Republic of China.

Cancer Letters
|December 24, 2021
PubMed

Insights

Yes-associated protein (YAP) and Transcriptional coactivator with PDZ-binding motif (TAZ) are key Hippo pathway effectors involved in organ growth and cancer. This review summarizes their upstream regulators and the transcription factors they partner with in various cancers.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • The Hippo pathway regulates organ size and is crucial in development and disease.
  • Yes-associated protein (YAP) and Transcriptional coactivator with PDZ-binding motif (TAZ) are central downstream effectors of the Hippo pathway.
  • YAP/TAZ lack DNA-binding domains, functioning as coactivators with other transcription factors.

Purpose of the Study:

  • To provide an overview of the Hippo-YAP/TAZ signaling pathway in mammals.
  • To systematically summarize transcription factors and partners mediating YAP/TAZ transcriptional output in cancers.
  • To highlight the role of YAP/TAZ in tumorigenesis.

Main Methods:

  • Literature review of Hippo pathway components and regulators.
  • Systematic summary of YAP/TAZ-interacting transcription factors.
  • Analysis of YAP/TAZ roles in various cancer types.

Main Results:

  • Detailed overview of core Hippo pathway components and upstream regulators.
  • Compilation of identified transcription factors and partners cooperating with YAP/TAZ.
  • Evidence linking YAP/TAZ to diverse cancer pathologies.

Conclusions:

  • The Hippo-YAP/TAZ pathway is a critical regulator of organ size, regeneration, and tumorigenesis.
  • Understanding YAP/TAZ partners is essential for elucidating their oncogenic roles.
  • This review provides a comprehensive resource on YAP/TAZ transcriptional regulation in cancer.
Keywords:
CancerCoactivatorContext-dependentHippo-YAP/TAZ signalingTransriptional regulation

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