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Crosstalk between non-coding RNAs expression profile, drug resistance and immune response in breast cancer

Seyed Ali Miraghel1, Nasim Ebrahimi2, Leila Khani3

  • 1Division of Biotechnology, Faculty of veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.

Pharmacological Research
|December 24, 2021
PubMed

Insights

Drug resistance in breast cancer is a major hurdle. This review explores how non-coding RNAs (ncRNAs) influence resistance to chemical drugs and immune checkpoint inhibitors (ICIs), offering insights for better treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Drug resistance presents a significant challenge in breast cancer treatment, limiting the efficacy of conventional therapies, monoclonal antibodies, and immune checkpoint inhibitors (ICIs).
  • Understanding the molecular mechanisms underlying drug resistance is crucial for developing more effective therapeutic strategies.
  • Non-coding RNAs (ncRNAs) have emerged as key regulators of gene expression and cellular processes, potentially playing a role in drug resistance phenotypes.

Purpose of the Study:

  • To review the current understanding of non-coding RNAs (ncRNAs) in the context of breast cancer drug resistance.
  • To investigate the role of microRNAs and long non-coding RNAs in resistance to both chemical drugs and immune checkpoint inhibitors (ICIs).
  • To highlight the potential of targeting ncRNAs for overcoming treatment resistance in breast cancer.

Main Methods:

  • Literature review of studies investigating ncRNAs and drug resistance in breast cancer.
  • Analysis of research focusing on microRNAs and long non-coding RNAs.
  • Synthesis of findings related to chemical drug resistance and ICI resistance.

Main Results:

  • Non-coding RNAs (ncRNAs), including microRNAs and long non-coding RNAs, are implicated in regulating gene expression profiles associated with drug resistance.
  • Altered expression and mechanisms of ncRNAs contribute to resistance against various breast cancer treatments.
  • Studying ncRNAs collectively for both chemical and ICI resistance provides a comprehensive view of their regulatory roles.

Conclusions:

  • Non-coding RNAs (ncRNAs) are critical regulators in breast cancer drug resistance.
  • Targeting specific ncRNAs may offer novel therapeutic avenues to overcome resistance to chemical drugs and ICIs.
  • Further research into ncRNA mechanisms is essential for personalized breast cancer treatment strategies.
Keywords:
Breast cancerDrug resistanceImmune checkpoint inhibitorsLncRNAsMicroRNAsNcRNAs

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